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    首頁> 外文期刊>Biochimica et Biophysica Acta. Molecular and cell biology of Lipids >The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes.
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    The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes.

    機譯：細胞膽固醇出口商ABCA1作為心血管疾病和糖尿病的保護者。

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    摘要

    ATP-binding cassette transporter A1 (ABCA1) is an integral cell membrane protein that exports cholesterol from cells and suppresses macrophage inflammation. ABCA1 exports cholesterol by a multistep pathway that involves forming cell-surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes. Thus, ABCA1 behaves both as a lipid exporter and a signaling receptor. ABCA1 transcription is highly induced by sterols, and its expression and activity are regulated post-transcriptionally by diverse processes. ABCA1 mutations can reduce plasma HDL levels, accelerate cardiovascular disease, and increase the risk for type 2 diabetes. Genetic manipulations of ABCA1 expression in mice also affect plasma HDL levels, inflammation, atherogenesis, and pancreatic beta cell function. Metabolites elevated in individuals with the metabolic syndrome and diabetes destabilize ABCA1 protein and decrease cholesterol export from macrophages, raising the possibility that an impaired ABCA1 pathway contributes to the enhanced atherogenesis associated with common inflammatory and metabolic disorders. The ABCA1 pathway has therefore become a promising new therapeutic target for treating cardiovascular disease and diabetes.
    機譯：ATP結合盒轉運蛋白A1（ABCA1）是一種完整的細胞膜蛋白，可從細胞輸出膽固醇并抑制巨噬細胞炎癥。 ABCA1通過多步途徑輸出膽固醇，該過程涉及形成細胞表面脂質結構域，通過載脂蛋白溶解這些脂質，載脂蛋白與ABCA1結合以及激活信號傳導過程。因此，ABCA1既充當脂質輸出者，又充當信號受體。固醇高度誘導ABCA1轉錄，其表達和活性在轉錄后受到多種過程的調節。 ABCA1突變可降低血漿HDL水平，加速心血管疾病并增加2型糖尿病的風險。小鼠中ABCA1表達的遺傳操作也會影響血漿HDL水平，炎癥，動脈粥樣硬化和胰腺β細胞功能?；加写x綜合癥和糖尿病的人體內代謝產物升高會破壞ABCA1蛋白的穩定性，并降低巨噬細胞的膽固醇輸出，從而增加了受損的ABCA1途徑促成與常見炎癥和代謝性疾病相關的動脈粥樣硬化形成的可能性。因此，ABCA1途徑已經成為治療心血管疾病和糖尿病的有希望的新治療靶標。

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