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    中國中醫藥信息雜志

    中國中醫藥信息雜志

    CSCD

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    Chinese Journal of Information on Traditional Chinese Medicine
    《中國中醫藥信息雜志》是由國家中醫藥管理局主管,中國中醫科學院中醫藥信息研究所主辦的國家級專業性學術期刊,被評為“全國中醫藥優秀期刊”、“中國科技核心期刊”。本刊立足于行業報道的前沿,關注相關的政策動態、重大課題的進展及中醫藥研究狀況,及時分析報道國內外傳統醫藥學的新政策、新動態、新進展、新成果、新技術、新療法、新思維、新市場,以實用為目的,將臨床、科研、管理、生產開發、市場營銷、教學等各部門緊密地結合起來,是行業各界在新形勢下獲取信息、把握機遇、尋求合作、走向成功的重要橋梁。
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    • 發文量：14061
    • 被引量：5086
    • H指數：2
    • 開始收錄時間：1994(1)
    • CNKI綜合因子：0.94
    • 維普期刊影響因子： 2.1
    • 萬方期刊影響因子：1.26
    • 創刊時間：1994
    • 國內刊號/CN：11-3519/R
      國際刊號/ISSN：1005-5304
    • 發行周期：月刊
      郵發代號：82-670
    • 主管單位：國家中醫藥管理局
      主辦單位：中國中醫科學院中醫藥信息研究所
    中國中醫藥信息雜志-聯系信息
    • 主編：葉祖光
    • 電話：010-64089637 64089575
    • 郵箱：[email protected]
    • 地址：北京東直門內南小街16號
    • 郵編：100700
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    中國中醫藥信息雜志 >2023年第5期

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    • 摘要：目的：建立三黃栓的質量控制方法。方法采用薄層色譜法鑒別三黃栓中的黃連、黃芩、黃柏。采用高效液相色譜法測定制劑中黃芩苷、鹽酸小檗堿的含量,色譜柱為Aglient ZORBAXSB-C18(4.6 mm×250 mm,0.45μm),甲醇-水-磷酸(47∶53∶0.2)為流動相,流速為1.0 mL/min,檢測波長黃芩苷為280 nm、鹽酸小檗堿為365 nm,柱溫30℃。結果定性鑒別色譜特征明顯。黃芩苷在0.248～2.48μg線性關系良好(r＝0.9999),平均回收率為99.77%,RSD＝1.05%；鹽酸小檗堿在0.336～1.68μg線性關系良好(r＝0.9999),平均回收率為97.74%,RSD＝1.48%。結論該定性定量檢測方法簡便可行,可有效控制該制劑質量。%Objective To establish the quality control method for Sanhuang Suppository. Methods Coptidis rhizoma, Scutellariae radix and Phellodendri chinensis cortex in Sanhuang Suppository were identified by TLC. The contents of baicalin and berberine hydrocholride were determined by HPLC which was performed on an Agilent Zorbaxsb C18 column (4.6 mm×250 mm, 0.45 μm) with a mobile phase of methanol-water-phosphoric acid (47∶53∶0.2), with flow rate of 1.0 mL/min. The wavelength of detector was set at 280 nm for baicalin and 365 nm for berberine hydrochloride, with column temperature of 30℃.Results Chromatographic characteristics of qualitative identification were evident. The linear range of baicalin was 0.248-2.48 μg (r=0.999 9) and the average recovery rate was 99.77% (RSD=1.05%). The linear range of berberine hydrocholride was 0.336-1.68 μg (r=0.999 9) and the average recovery rate was 97.74% (RSD=1.48%).Conclusion The method of qualitative and quantitative analysis is accurate, feasible and suitable for effective quality control of Sanhuang Suppository.
    • 摘要：周圍性面神經麻痹是以口眼歪斜、表情動作喪失為主要癥狀的周圍性面神經疾病。目前主要有藥物治療、手術療法、星狀神經節阻滯治療、針刺療法等。筆者采用正清風痛寧注射液穴位注射治療急性期周圍性面神經麻痹，取得較好療效，現報道如下。
    • 摘要：骨髓增生異常綜合征（MDS）是指一組異質性的克隆性疾病，特點是髓系細胞分化、成熟異常，無效造血，或造血功能衰竭，以及因遺傳不穩定而導致的高風險向急性髓系白血?。ˋML）轉化，其臨床表現為面色蒼白、乏力、活動后心悸、氣短、出血、發熱、脾大等。MDS屬中醫“虛勞”、“血證”、“癥積”等范疇。為便于臨床規范，目前專家已達成共識[1]，將MDS的中醫病名定為“髓毒勞”，其中“髓”代表病位，“毒”代表病性，“勞”代表病狀。
    • 摘要：因參加國家中醫藥管理局“第二批全國優秀臨床人才研修項目”學習，筆者有幸跟隨首批國醫大師朱良春教授學習，侍診朱老左右1年，耳聞目睹，獲益匪淺。朱老擅治疑難病證，尤以善用蟲類藥和善治痹證著稱，首倡辨證論治與辨病論治相結合。2011年，蒙朱老之女朱婉華院長相邀，參加南通良春中醫醫院國家中醫藥管理局“十一五”重點?？平ㄔO項目“痛風中醫臨床路徑管理試點工作”，師姐更將先生經驗悉數相傳，精心指導。2年來，筆者以朱老經驗治療痛風數十人，均獲良效?，F舉驗案三則介紹如下。
    • 摘要：目的：了解甘肅省2010-2012年中藥材、中藥飲片質量情況。方法選擇甘肅省14個地州市2010-2012年15個品種865批中藥材、中藥飲片,按評價性抽驗規定的檢驗方法進行檢驗,從不合格項目、抽樣單位性質來進行評價。結果本次甘肅省甘南藏族自治州食品藥品檢驗檢測所承擔的中藥材、中藥飲片共15個品種865批次,有260批不合格,其中發現99批為偽品,104批為摻偽,總不合格率為30.1%。結論目前甘肅省中藥材、中藥飲片質量問題令人擔憂,建議盡快加強市場監督管理,提高中藥材質量已刻不容緩。%ObjectiveTo examine the quality of Chinese herbal pieces Traditional Chinese Herbal Medicine (Chinese Herbal Pieces) in Guasu Province during 2010 to 2012.MethodsBy using the examination method according to selective examination requirements, 15 varieties of 865 batches of Chinese herbal medicine from 14 regions in Gansu Province during 2010 to 2012 were examined. Evaluation was conducted from the unqualified items and sample quality.Results Among 15 varieties of 865 batches of Chinese herbal medicine from Tibetan Autonomous Prefecture of Gannan in Gansu Province, 240 batches were unqualified, including 99 batches of fake, 104 batches of adulteration, the total fraction defective was 30.1%.ConclusionThe problems in quality of Traditional Chinese Herbal Medicine (Chinese Herbal Pieces) in Gansu Province are serious. Therefore, TCM market inspection and management should be reinforced and the quality of Chinese herbal medicine should be improved as soon as possible.
    • 摘要：目的：系統評價針灸豐隆治療高脂血癥的有效性和安全性。方法計算機檢索 PubMed、EMbase、Cochrane圖書館、中國期刊全文數據庫、中文科技期刊數據庫、中國生物醫學文獻數據庫和萬方數據庫,并輔以手工檢索,納入針灸豐隆與口服藥物比較治療高脂血癥的隨機對照試驗(RCT)。對納入研究文獻進行質量評價,并提取有效數據,采用RevMan5.0軟件進行Meta分析。結果共納入6個RCT,包括701例患者。Meta分析顯示,針灸豐隆與口服他汀類或血脂康膠囊比較,有效率差異均無統計學意義；針灸豐隆與他汀類藥物比較,在降低膽固醇、升高高密度脂蛋白膽固醇方面有一定優勢,且不良反應少。結論針灸豐隆治療高脂血癥安全、有效,但尚需有更多、更高質量的RCT加以驗證。%Objective To systematically review the efficacy and safety of acupuncture and moxibustion at Fenglong point (ST40) for the treatment of hyperlipemia.Methods Systematic searches were conducted in PubMed, EMbase, the Cochrane Library, CNKI, VIP, CBM and WanFang Data, assisted by manual retrieval, and the RCTs of comparative study on acupuncture and moxibustion at Fenglong point and oral administration drugs were included. Data were extracted and evaluated by two reviewers independently with a specially-designed extraction form. The Cochrane Collaboration's RevMan 5.0 software was used for Meta analysis.Results A total of 6 RCTs involving 701 patients were included. The results of Meta analysis showed that the total effective rate in acupuncture and moxibustion at Fenglong point for the treatment of hyperlipemia was similar with statins medicine or Xuezhikang capsule. Acupuncture Fenglong point and statins medicine had significant difference in decreasing cholesterol and increasing HDL-C, with less side effects.Conclusion Acupuncture at Fenglong point is safe and effective in the treatment of hyperlipemia, but still needs more high-quality RCTs for confirmation.
    • 摘要：Objective To explore the regularities and rules of compound herbal formulae for nonalcoholic fatty liver disease (NAFLD).Methods Compound herbal formulae on NAFLD published in journals of CNKI (1979.1-2014.1), VIP (1989.1-2014.1) and CBMdisc (1979.1-2014.1) were analyzed with association rule, frequency analysis and cluster analysis.Results In 107 prescriptions, 179 herbs were involved, and frequency of usage of those herbs was 1499. A cluster analysis was used to analyze 37 herbs with high frequency (≥10) of usage, which were classified into 9 clusters including promoting circulation, clearing heat herb, diuretic herb, food stagnation herb, regulating qi herb, phlegm-resolving herb, qi tonics herb, yin-nourishing herb, qi-activating herb and purgating herb. 30 pairs of herbs and 33 rules for NAFLD were obtained by association rule analysis.Conclusion It was a point of view to understand the regularities and rules of Chinese herb prescription on NAFLD by data mining.%目的：探討中藥復方治療非酒精性脂肪肝的用藥規律。方法檢索中國期刊全文數據庫(1979年1月-2014年1月)、中文科技期刊數據庫(1989年1月-2014年1月)和中國生物醫學文獻數據庫(1979年1月-2014年1月)公開發表文獻中治療非酒精性脂肪肝的中藥復方，建立相應數據庫，采用頻次分析、聚類分析和關聯規則分析方法對中藥復方進行數據挖掘。結果共獲得治療非酒精性脂肪肝的中藥復方107個，涉及藥物179種、頻次1499次；以使用頻次≥10次的37種作為主要藥物進行聚類分析，歸為活血藥、清熱藥、利濕藥、補氣藥、消積藥、化痰藥、補陰藥、行氣藥和瀉下9大類；經關聯規則分析，共得有趣關聯規則33條，藥對30對。結論數據挖掘有助于解讀中藥復方治療非酒精性脂肪肝的用藥規律。
    • 摘要：目的：觀察三七總皂苷對β-淀粉樣蛋白(Aβ)42損傷腦微血管內皮細胞ZO-1表達的影響,為阿爾茨海默病的對因治療提供新的依據。方法細胞分為正常對照組、模型組和三七總皂苷低、中、高劑量組,37℃、5%CO2培養箱中培養24 h后,采用MTT比色法檢測細胞活力,Western blot檢測ZO-1蛋白表達。結果 Aβ42刺激后微血管內皮細胞活力降低(P＜0.01),ZO-1蛋白表達被抑制(P＜0.01)；與模型組比較,三七總皂苷低、中、高劑量組微血管內皮細胞活力增加,其中三七總皂苷中、高劑量組增加較為明顯,差異有統計學意義(P＜0.05),ZO-1蛋白表達增加。結論三七總皂苷通過抑制Aβ42所致微血管內皮細胞活力降低,恢復血腦屏障的部分屏障功能。%Objective To study the effects of Panax Notoginseng Saponins (PNS) on the damaged expression of ZO-1 of brain microvascular endothelial cells caused by Aβ42.MethodsBrain microvascular endothelial cells were divided into normal control group, model group, PNS low-, medium- and high concentration groups. They were incubated for 24h in 5% CO2 incubator at 37℃ . Then cell vitality was detected by MTT colorimetric method and ZO-1 protein expression was tested by Western blot.Results Stimulation of Aβ42 reduced the activity of microvascular endothelial cells (P<0.01) and suppressed the expression of ZO-1 protein (P<0.01). Compared with the model group, the activity of microvascular endothelial cells of PNS groups, especially the high and medium dose groups (P<0.05), and increased the ZO-1 protein expression. Conclusion PNS can partly recover the barrier function of blood brain barrier through inhibiting the decrease of the activity of microvascular endothelial cells caused by Aβ42.
    • 摘要：目的：觀察散血草水提物對胃潰瘍小鼠的影響,為臨床應用提供實驗依據。方法采用利血平誘導制作胃潰瘍動物模型。實驗小鼠隨機分為正常組、模型組、散血草低劑量組、散血草高劑量組、雷尼替丁組,各給藥組給予相應藥物灌胃,正常組和模型組給予等量生理鹽水,連續4周。測定胃潰瘍面積、胃液量和胃液酸度,酶聯免疫法檢測血清中相關因子水平,RT-PCR法檢測胃組織誘導型一氧化氮合酶(iNOS)、環氧化酶-2(COX-2)基因表達。結果與模型組比較,散血草低、高劑量組胃潰瘍面積明顯減少,血清中生長抑素和血管活性腸肽水平升高,胃動素和P物質水平降低(P＜0.05,P＜0.01)；散血草低、高劑量組白細胞介素(IL)-6、IL-12、腫瘤壞死因子-α、γ-干擾素水平及iNOS、COX-2基因表達水平降低(P＜0.05,P＜0.01)。結論散血草具有較好的抗胃潰瘍作用,散血草高劑量組表現更優。%Objective To observe effects of aqueous extractive of Clarke boea herb on mice with gastric ulcer, and provide basis for clinical application.Methods Gastric ulcer model was induced by reserpine. The mice were divided into normal group, model group, ranitidine group, low and high dose of Clarke boea herb groups. Mice in treatment groups were given corresponding drugs by gavage, and the normal group and control group were given the same amount of saline for 4 weeks. The area of gastric ulcer, serum proinflammatory cytokines gastric juice volume, gastric juice acidity, iNOS and COX-2 gene expressions were detected.Results Compared with control group, the gastric ulcer area in low and high dose of Clarke boea herb groups decreased significantly. Clarke boea herb increased the SS and VIP, decreased the MOT and SP serum levels (P<0.05,P<0.01). Clarke boea herb reduced the levels of serum proinflammatory cytokines of IL-6, IL-12, TNF-α and IFN-γ(P<0.05,P<0.01). Clarke boea herb also decreased the genetic expressions of iNOS and COX-2 (P<0.05,P<0.01).ConclusionClarke boea herb has good gastric ulcer preventive effects, and the high dose of Clarke boea herb group showed the best efficiency.
    • 摘要：Objective To determine the best extraction process of ginkgo leaves with the total transfer rate of total flavonol glycosides and terpene lactones as the index.Methods The effects of ethanol concentration, solid-liquid ratio and extraction time on extraction process were investigated by orthogonal design method, and the contents of total flavonol glycosides and terpene lactones were detected by HPLC to calculate transfer rate.Results The optimum extraction conditions were as follows:85% ethanol refluxing and extracting for three times;the first time extracting with five-fold amount of solvent (V/W) for 3 hours;the last two times with three-fold solvent (V/W) for 2 hours.Conclusion This extraction process has the advantages of simplicity of operator, reason, energy conservation, high efficiency, and is suitable for industrial production.%目的：以總黃酮醇苷、萜類內酯的綜合轉移率為指標,確定銀杏葉最佳提取工藝。方法采用正交設計方法,系統考察乙醇濃度、料液比、提取時間3個因素對銀杏葉提取工藝的影響,利用高效液相色譜法測定總黃酮醇苷、萜類內酯的含量,計算轉移率。結果最佳提取工藝條件為：采用85%乙醇加熱回流提取3次,第1次加5倍量(V/W)溶劑提取3 h,后2次分別加入3倍量(V/W)溶劑提取2 h。結論本工藝操作簡單、合理、節能、高效,適用于工業化生產。
    • 摘要：卵巢早衰（premature ovarian failure,POF）指婦女在40歲之前由某種原因引起的以閉經、不孕、雌激素缺乏、促性腺激素水平升高為特征的一種疾病,常伴隨烘熱汗出、煩躁失眠等表現。筆者采用針藥結合療法治療POF患者40例,并與西藥人工周期法進行對比觀察,現報道如下。
    • 摘要：痰是由于體內水液運行異常，導致水液停留凝聚而形成的一種病理產物。中醫有“百病皆由痰作祟”之說，表明痰是導致諸多疾病發生和發展的重要因素。痰既可停聚于臟腑、經絡、組織之間，又可隨氣機上下內外竄動，無處不在，正如《雜病源流犀燭》所說：“痰之為物，流動不測，故其為害，上至巔頂，下至涌泉，隨氣升降，周身內外皆到，五臟六腑俱有?！碧涤袝r難以被察覺，但在脈象上卻有明顯的特征顯現，因此，探討痰脈的特征表現及演變規律，對痰邪致病的辨治具有重要的意義。
    • 摘要：本院曾慶祥主任醫師是深圳市名中醫藥專家學術經驗繼承工作的指導老師，融會貫通中西醫理論，兼收并蓄，擷采其長，為己所用，并長期堅持在臨床的第一線，精勤不倦，師古而不泥今，治病不拘一格，尤其對神經系統疾病頗有研究。曾師善于運用脾胃學說從調補脾胃補益后天之本的角度出發治療神經系統疾病，臨床療效頗佳。筆者作為其學術繼承人，有幸拜于曾師門下，深得教誨，受益良多，今不揣愚陋，將曾師相關臨床經驗介紹如下，以饗同道。
    • 摘要：目的：分析螺旋進度教學法與傳統教學法應用于高等中醫院校計算機教學的效果差別。方法將學生分為螺旋進度教學法組和傳統教學法組進行教學活動，課程結束后進行考核。結果螺旋進度教學法組學生考試成績優于傳統教學法組(P＜0.05)。結論螺旋進度教學法運用于高等中醫院校計算機教學，有助于培養學生正確的思維模式、良好的學習方法，并提高了學生將計算機基本理論知識應用于中醫藥學習和研究的能力。%ObjectiveTo analyze the different effects of spiral progress method and traditional method used in computer teaching in TCM colleges and universities.MethodsStudents were divided into the groups of spiral and traditional. At the end of the course, students would have a course examination.Results Students in spiral group got better scores than students in traditional group (P<0.05).Conclusion Using spiral progress method in computer teaching in TCM colleges and universities can help students develop the right thinking model and scientific learning method. It can also improve students’ ability to use computer knowledge in TCM study and research.
    • 摘要：“九針”作為規范的名詞術語在《內經》中多次出現，其中《靈樞》部分開篇即為《九針十二原》，可見“九針”的重要性。本文從術語角度對九針之源、九針之名、九針之形、九針之功、九針之使用要領和九針之應6個方面進行論述，探析其內涵。%As a normative technical term, “nine needles” appears repeatedly inThe Internal Canon of Medicine, in which Miraculous Pivot set theNine Needles and Twelve Source Acupoints as the first passage. Therefore, the significance of “nine needles” is evident. This article expounded “nine needles” from the following six aspects:the origin, the name, the types, the functions, the use and the application, with a purpose to standardize the contents of “nine needles”, and analyse the connotation.
    • 摘要：目的：觀察針刺聯合鹽酸帕羅西汀片治療輕中度抑郁癥臨床療效及其不良反應。方法將73例輕中度抑郁癥患者隨機分為2組。觀察組40例,予針刺及鹽酸帕羅西汀片口服；對照組33例,僅予鹽酸帕羅西汀片口服。療程6周。觀察2組臨床療效,治療前及治療1、2、4、6周漢密頓抑郁量表(HAMD),治療前及治療2、4、6周抗抑郁藥副反應量表(SERS)評分。結果觀察組臨床總有效率為78.95%(30/38),對照組為68.75%(22/32),差異無統計學意義(P＞0.05)。觀察組治療2、4、6周HAMD評分明顯降低(P＜0.05,P＜0.01),對照組治療4、6周HAMD評分明顯降低(P＜0.05),治療4周時2組HAMD評分比較差異有統計學意義(P＜0.05)。2組治療4、6周SERS評分比較差異有統計學意義(P＜0.05)。結論針刺聯合鹽酸帕羅西汀片抗抑郁效果顯著且能減少不良反應。%Objective To observe the clinical efficacy and reverse reactions of acupuncture combined with paroxetine hydrochloride in the treatment of mild or moderate depression. Methods The patients with mild or moderate depression (n=73) were randomly divided into control group (treated with paroxetine hydrochloride,n=33) and observation group (treated with acupuncture and paroxetine hydrochloride,n=40). The therapeutic course lasted for 6 weeks. The total score changes of Hamilton Depression Scale (HAMD) were observed before treatment and treated for 1, 2, 4 and 6 weeks. Rating Scale for Side Effects (SERS) was evaluated before treatment and treated for 2, 4, 6 weeks.Results The total effective rate of clinical efficacy in the observation group was 78.95% (30/38) and the control group was 68.75% (22/32), without significant difference between the two groups (P>0.05). The scores of HAMD decreased 4, 6 weeks after the treatment in the control group and 2, 4, 6 week after the treatment in the observation group compared with those in the same group before the treatment (P<0.05,P<0.01). There was a significant difference in HAMD scores between two groups after the treatment for 4 weeks (P<0.05). The scores of SERS showed a significant difference 4, 6 weeks after the treatment between the two groups (P<0.05).Conclusion Acupuncture can improve the curative effect of paroxetine hydrochloride and decrease its side effects in the treatment of depression.
    • 摘要：Objective To observe the effects of intervention of soothing liver and activating blood Chinese medicine on cardiac function and myocardial pathologic morphology of BMSCs transplanting on myocardial IRI of rats, and investigate its myocardial protection mechanism. Methods Model of myocardial IRI was established by coronary artery ligation in rats. SD rats were randomly divided into sham operation group, IRI group, BMSCs group and combined group. Rats in combined group were filled the stomach with soothing liver and activating blood Chinese medicine, and rats in other groups were filled the stomach with the same dose of normal saline. After 4 weeks, myocardial pathologic morphology was observed with light microscope. Cardiac function was detected with ultrasonic cardiogram.Results Compared with BMSCs group, heart function of the combined group improved, with significant statistical difference (P<0.05,P<0.01). Pathological observation showed that myocardial structure and pathological morphology were obviously promoted in the combined group.Conclusion Soothing liver and activating blood Chinese medicine could improve heart function and myocardial pathological morphology of IRI rats with BMSCs transplantation.%目的：觀察疏肝活血中藥對骨髓間充質干細胞(BMSCs)移植心肌缺血再灌注損傷(IRI)大鼠心功能和心肌病理形態的影響,探討其對心肌保護的作用機制。方法采用結扎冠關動脈方法制備心肌IRI模型。SD大鼠隨機分為假手術組、IRI組、BMSCs組和疏肝活血中藥＋BMSCs聯合組(聯合組),聯合組予以疏肝活血中藥灌胃,其余各組灌胃等量生理鹽水。4周后,光鏡下觀察心肌病理形態,超聲心動圖檢測心功能。結果與 BMSCs組比較,聯合組心功能明顯改善,差異有統計學意義(P＜0.05,P＜0.01)；病理形態觀察顯示,聯合組可以明顯改善大鼠心肌結構和病理形態。結論疏肝活血中藥可以改善BMSCs移植IRI大鼠心肌病理形態和心功能。
    • 摘要：目的：探討升清中藥抑制飲食誘導肥胖(DIO)大鼠肥胖及瘦素抵抗的作用機制。方法取 Wistar大鼠,制作DIO大鼠40只和DIO抵抗(DIO-R)大鼠10只。DIO大鼠分為模型組、西布曲明組、健脾理氣組、升清組,每日分別以生理鹽水、西布曲明、健脾理氣藥物(陳皮、木香、枳實)、升清藥物(柴胡、升麻、葛根)灌胃,空白組與DIO-R組予生理鹽水,灌胃16周。測定干預前后體質量,檢測干預后血清神經肽Y(NPY)、瘦素和脂肪瘦素、細胞因子信號傳導抑制因子3(SOCS-3)。結果與DIO-R組比較,模型組體質量增加、NPY升高(P＜0.01),血清和脂肪瘦素降低(P＜0.05),SOCS-3升高(P＜0.05)。藥物干預后,各藥物組體質量有所下降。健脾理氣組脂肪瘦素升高(P＜0.05)；升清組在升高瘦素、降低體質量和 NPY、SOCS-3水平方面,優于西布曲明組和健脾理氣組,差異有統計學意義(P＜0.05,P＜0.01)。結論升清藥物能減輕肥胖,抑制瘦素抵抗。%Objective To observe the effects of Shengqing Chinese herbs on the obesity and leptin resistance of diet-induced obesity (DIO) rats.Methods Wistar rats were produced a rat model including of 40 DIO rats and 10 DIO-R rats. The DIO rats were divided into DIO model group, sibutramine group, Jianpi Liqi group and Shengqing group, which were respectively by gavage of saline, sibutramine, Jianpi Liqi herbs (Citri reticulatae pericarpium, Aucklandiae radix, Aurantii fructus immaturus), Shengqing herbs (Bupleuri radix, Cimicifugae rhizoma, Puerariae lobatae radix), blank control group and DIO-R group were by gavage of saline. Their weight, were examined after 16 weeks gavage. Leptin and neuropeptide Y in the serum were examined. Leptin, TNF-α, and suppressors of cytokine signaling-3 (SOCS-3) in the homogenized fat were examined. Results Compared with the DIO-R group, DIO model group's body weight, NPY significantly increased (P<0.01);leptin in the serum and homogenized fat decreased (P<0.05);SOCS-3 increased (P<0.05). After drug intervention, weight of each drug group declined. Compared with the DIO model group, Jianpi Liqi group's leptin in the homogenized fat increased (P<0.05). Shengqing group's leptin in homogenized fat increased, body weight reduced, NPY and SOCS-3 levels decreased, and better than sibutramine group and Jianpi Liqi group (P<0.05,P<0.01).Conclusion Shengqing herbs can reduce obesity and inhibit leptin resistance.
    • 摘要：目的：優選溫陽通便顆粒中當歸、肉桂揮發油的最佳提取工藝條件。方法采用水蒸氣蒸餾輕油裝置加乙醚萃取的方法提取當歸、肉桂揮發油,以揮發油收率作為評價指標,選擇浸泡時間、加水量及提取時間為主要影響因素,應用L9(34)正交試驗設計,選取最佳提取工藝條件。結果水蒸氣蒸餾法提取當歸、肉桂揮發油的最佳工藝條件為：藥材浸泡3 h,加10倍量水,蒸餾提取6 h。結論本試驗優選所得提取工藝條件穩定可行。%Objective To optimize the extraction conditions of volatile oil from Angelica Sinensis and Cassia Bark in Wenyang purgation granules.Methods The volatile oil was extracted from Angelica Sinensis and Cassia Bark by the method of steam distillation light oil device with diethyl ether extraction. The yield of the volatile oil was chosen as the evaluation index. The time of dip in water, the ratio of water to herbal medicine material and the time of distillation were used as the main factors. The optimum extraction conditions were investigated by the L9(34) orthogonal design. Results The optimal conditions for extraction process of volatile oil from Angelica Sinensis and Cassia Bark in Wenyang purgation granules were as follows:the time of dip in water was 3 h;the ratio of water to herbal medicine material was 10∶1;the time of distillation was 6 h. Conclusion The optimized conditions of extraction process are stable and feasible.
    • 摘要：骨轉移是晚期惡性腫瘤的常見并發癥，由此引發的癌性疼痛嚴重影響患者食欲、睡眠及免疫功能。目前治療以雙膦酸鹽類及阿片類藥物應用最為廣泛。復方苦參注射液有防止腫瘤復發轉移、提高免疫力和控制癌痛等作用[1]。筆者采用回顧性研究方法，分析本院既往使用復方苦參注射液控制骨轉移疼痛的治療情況，現報道如下。
    • 摘要：Objective To discuss the teaching outcomes of problem-based learning method in classroom teaching of TCM pharmaceutics.Methods Fifty students majoring in 2009 science of Chinese materia medica were taught by using traditional teaching method in teaching of TCM pharmaceutics, and 56 students majoring in 2009 TCM pharmaceutics by using of problem-based learning method. This study evaluated students’ adaption to the two teaching methods through score analysis and questionnaire of the two classes.Results Students taught by problem-based learning method generally believed that this teaching method can stimulate their learning interest, improve self-study ability, thinking ability, creativity, and language competence, and enhance team spirit.Conclusion Problem-based learning method shows better teaching outcomes than traditional teaching method. It can guide students to look for ways to tackle problems in the course of solving problems, and cultivate all-round ability and comprehensive quality of students.%目的：探討以問題為基礎的互動式教學法(PBL)在中藥藥劑學課堂教學中的效果。方法對2009級中藥學專業50名學生采用傳統教學法進行中藥藥劑學的課堂授課,2009級藥物制劑學專業56名學生采用PBL,通過對2個班學生的成績分析與問卷調查,評價學生對兩種教學方法的適應性。結果在實施PBL后,學生普遍認為該方法能激發學習興趣,提高自學能力、思考能力、創新能力、語言表達能力,增進團隊合作精神；運用該方法后學生考試成績明顯提高。結論 PBL 比傳統教學模式效果更好,能在解決問題的過程中引導學生尋找解決問題的方法與途徑,培養學生的多種能力和綜合素質。
    • 摘要：類風濕關節炎(RA)是一種以慢性破壞性關節病變為主要特征的自身免疫性疾病?；ぱ苄律荝A發病過程中出現較早且至關重要的因素，以滑膜血管為靶標已成為治療RA的新策略。中藥治療RA歷史悠久，并顯示出較好的抗RA作用。本文就近年中藥抗滑膜血管新生作用的研究狀況加以整理，為進一步深入研究中藥抗RA作用提供參考。
    • 摘要：With the continuous development of modern chemistry, biology and pharmacy, researches on TCM modernization has witnessed a wide range of application of related modern technology, especially in researches of TCM monomer efficacy and pharmacokinetics. This can provide basis to internationalization of traditional Chinese medicine. The current research focus is how to obtain targeted TCM monomer. This article expounded the screening methods for TCM monomer at home and abroad, the principles of screening, the limitation and meanings.%隨著現代化學、生物學及藥學等領域日新月異的進步，相關現代技術在中藥現代化的研究中得到了廣泛的應用，特別是對中藥單體的藥效和藥代研究的進展，為中藥走向國際提供了基礎。如何獲得目的中藥單體成為目前研發的熱點和焦點。本文就目前國內外有關中藥單體的篩選方法、不同篩選類型原理、局限性及意義進行了闡述。
    • 摘要：Objective To observe the clinical efficacy of Ziyin Yikang Recipe plus hexadecadrol on anti-HCG antibody positive secondary sterility and the influence on anti-HCG antibody titers. Methods Sixty patients with anti-HCG antibody positive secondary sterility were randomly divided into treatment group (TG) and control group (CG), 30 cases in each. Patients in the TG were treated with Ziyin Yikang Recipe plus hexadecadrol, while patients in the CG were given hexadecadrol only. The Chinese medicine symptom scores and changes of anti-HCG antibody titers were evaluated and compared between the two groups.Results The Chinese medicine symptom scores in the two groups decreased compared with those before treatment (P<0.05), and the TG showed a more significant decrease than the CG (P<0.05). The anti-HCG antibody titers in both groups dropped compared with those before treatment (P<0.05, P<0.01). There was no statistically difference between the two group after treatment (P>0.05). The total effective rate in the TG was higher that that in the CG (P<0.05), with 63.33% (19/30) in the TG and 47.66% (14/30) in the CG.Conclusion The treatment of Ziyin Yikang Recipe plus hexadecadrol on anti-HCG positive secondary sterility can obviously improve the clinical syndrome of yin deficiency and fire hyperactivity, and promote pregnancy success.%目的：觀察滋陰抑抗湯聯合地塞米松治療抗人絨毛膜促性腺激素抗體(HCG-Ab)陽性繼發性不孕癥患者的臨床療效及對HCG-Ab滴度的影響。方法將60例HCG-Ab陽性的繼發性不孕癥患者隨機分為2組,每組30例。治療組予滋陰抑抗湯聯合地塞米松治療,對照組予單純地塞米松治療。觀察治療前后中醫臨床癥狀積分、HCG-Ab滴度變化,并比較2組臨床療效。結果2組中醫癥狀積分均較治療前顯著降低(P＜0.01),治療組優于對照組(P＜0.01)；2組HCG-Ab滴度均較治療前顯著降低(P＜0.05,P＜0.01),治療后2組比較,差異無統計學意義(P＞0.05)；治療組總有效率為63.33%(19/30),對照組為47.66%(14/30),治療組優于對照組(P＜0.05)。結論滋陰抑抗方聯合地塞米松能改善HCG-Ab陽性繼發性不孕患者的臨床癥狀,促進妊娠。
    • 摘要：Objective To evaluate the efficiency of Ginkgo biloba extract 50 (GBE50) on learning memory ability and inflammatory response in hippocampus of natural aging mice, and explore the underlying anti-aging mechanisms.Methods 16-month-old ICR mice were randomly divided into three groups:model group, GBE50 low and high dose groups. 1 month mice were as normal group. The mice in GBE50 low and high dose groups received GBE50. The mice in the normal and model groups received solvent (1%CMC-Na+) by intragastric administration. The Morris water maze test and step-down test were used to assess behaviors of the mice. Immunofluorescent staining was used to detect the number of Iba-1 positive cells. The enzyme linked immunosorbent assay was used to determine the expression of TNF-α and IL-1β.Results Compared with normal group, escape latency and swimming distance in the Morris water maze test in the model group increased (P<0.05);latency shorted and error times decreased in the step-down test (P<0.05);the number of Iba-1 positive cell in the hippocampus CA1 in the model group increased considerably (P<0.01);TNF-α expression was in a general upward trend while IL-1β increased apparently (P<0.01). Compared with model group, escape latency and swimming distance decreased in the Morris water maze test in GBE50 high dose group;latency and the error times increased in the step-down test (P<0.05);the number of Iba-1 positive cells decreased (P<0.05). TNF-α expression showed a downward trend and IL-1β expression decreased in GBE50 low dose group (P<0.05). Conclusion GBE50 can delay aging and increase learning memory of natural aging mice.%目的：觀察銀杏酮酯對自然衰老小鼠學習記憶能力和海馬神經炎癥反應的影響,探討銀杏酮酯抗衰老的作用機制。方法16月齡ICR小鼠隨機分為模型組和銀杏酮酯高、低劑量組,1月齡ICR小鼠作為正常組。其中銀杏酮酯高、低劑量組給予不同劑量的銀杏酮酯灌胃,模型組和正常組給予1%羧甲基纖維素鈉灌胃。采用Morris 水迷宮和跳臺實驗進行行為學檢測,免疫組織熒光化學方法檢測海馬離子鈣接頭蛋白抗原(Iba-1)數量,酶聯免疫吸附試驗測定海馬腫瘤壞死因子-α(TNF-α)和白細胞介素-1β(IL-1β)表達。結果與正常組比較,模型組 Morris 水迷宮的逃避潛伏期和游泳距離均延長(P＜0.05),跳臺實驗中潛伏期縮短和錯誤次數增加(P＜0.05),海馬Iba-1陽性細胞數增加(P＜0.01),TNF-α表達有上調趨勢,IL-1β表達上調(P＜0.01)；與模型組比較,銀杏酮酯高劑量組的逃避潛伏期和游泳距離有降低趨勢,跳臺實驗的潛伏期延長和錯誤次數降低(P＜0.05),海馬Iba-1陽性細胞數減少(P＜0.05)；銀杏酮酯低劑量組TNF-α表達有下降趨勢,IL-1β表達下降顯著(P＜0.01)。結論銀杏酮酯能增強自然衰老小鼠學習記憶能力,延緩衰老發生。
    • 摘要：目的：優選祖師麻凝膠膏劑的提取工藝。方法以祖師麻甲素含量為考察指標,以溶劑用量、浸泡時間、提取時間為考察因素,采用正交試驗進行工藝優選。結果祖師麻藥材的最佳提取工藝為：脫脂祖師麻藥材加水30 mL,浸泡1.5 h,回流提取2.0 h,提取1次。祖師麻甲素的平均含量為9.83 mg/g。結論該提取工藝穩定可行,節約能源,為祖師麻凝膠膏劑的生產工藝提供了依據。%Objective To optimize the extraction process of Zushima Gel Cream.Methods Setting the content of daphnetin as an investigating index, and the amount of solvent, soak time and the extraction time as investigating factors, the orthogonal experiment was used to optimize the extraction process.Results The best extraction process was as follows:adding 30 mL water to degreasing Zushima Gel Cream;soaking for half an hour;extracting one time for two hours. The average content of daphnetin was 9.83 mg/g.Conclusion The extraction process is stable, reliable, and energy-saving. The study provided experimental evidence for the preparation process of Zushima Gel Cream.
    • 摘要：Objective To optimize the processing technology for Radix Puerariae simmered with wheat bran.Methods Orthogonal experiment L9(34) was chosen to optimize the technology. The external properties of Radix Puerariae simmered by wheat bran, the content of puerarin and the antidiarrheal effect on mice with diarrhea caused by folium sennae were used as indexes. Comprehensive weighted score was employed to optimize simmering Radix Puerariae with wheat bran technology.Results Processing time was the main affecting factor, while processing temperature had no significant effect. The optimum processing parameters were 100 g Radix Puerariae simmered with 30 g wheat bran at 160℃ for 2 minutes.Conclusion The optimum processing technology was simple and convenient, and with good reproducibility and operability. It is also helpful for the quality control of Radix Puerariae simmered with wheat bran.%目的：優選麥麩煨制葛根的最佳炮制工藝。方法采用 L9(34)正交試驗法,以麥麩煨制葛根外觀性狀、葛根素含量和對番瀉葉所致小鼠腹瀉的止瀉作用為考察指標,用綜合加權評分法優選葛根麥麩煨制工藝。結果炮制時間為主要影響因素,炮制溫度影響不顯著。優選的炮制工藝為：每100 g葛根用麥麩30 g,160℃炮制2 min。結論優選得到的炮制工藝簡便易行,有良好的重復性和可操作性,有助于麥麩煨制葛根質量控制。
    • 摘要：經尿道前列腺電切術（TURP）是治療良性前列腺增生（BPH）的有效手段之一。TURP可解除患者尿路梗阻，但由于手術創傷及膀胱功能尚未恢復，術前下尿路癥候群（LUTS）如尿頻、尿急、夜尿增多和急迫性尿失禁等儲尿期癥狀常持續較長時間，甚至再次出現急性尿潴留等排尿期癥狀及血尿、泌尿系感染等手術后并發癥，嚴重影響患者的生活質量[1]。筆者在TURP術后患者中應用穴位貼敷療法，取得滿意效果，現報道如下。
    • 摘要：術后發熱是泌尿外科臨床常見并發癥。隨著廣譜抗生素的廣泛應用，耐藥菌株也相應增多，其導致的一些難治性發熱日益困擾臨床醫生。對此，筆者通過中醫辨證論治，運用參苓白術散加減治療，獲得滿意效果。茲介紹如下。

      中國中醫藥信息雜志的期刊信息

      • 曾用名：中國中醫藥情報雜志
      • 創刊時間：1994
      • 地區：CN
      • 語言：中文
      • 熱門主題：中國中醫科學院中醫藥信息研究所
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      中國中醫藥信息雜志的獲獎情況

      • ? 1995年獲首屆全國中醫藥優秀期刊評比三等獎
      • ? 2000年獲第二屆全國中醫藥優秀期刊評比三等獎

      中國中醫藥信息雜志的收錄情況

      • ? 農業與生物科學研究中心文摘
      • ? 化學文摘（網絡版）
      • ? 中國科學引文數據庫（2011-2012）
      • ? 中國科學引文數據庫（2013-2014）
      • ? 中國科學引文數據庫（2015-2016）
      • ? 中國科學引文數據庫（2017-2018）
      • ? 中國科學引文數據庫（2019-2020）
      • ? 哥白尼索引
      • ? 日本科學技術振興機構數據庫
      • ? 烏利希期刊指南
      • ? 中國科技核心期刊

      中國中醫藥信息雜志的投稿信息

      • 投稿方式：在線投稿
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      • 期刊欄目：名醫論壇；改革與管理；專題論壇；思路與方法；博士論壇；述評；研究與進展；科研動態

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